The A160 was closed for 15 minutes at the Habrough and South Killingholme junction after a forklift truck fell off the back of a low-loader.
Humberside Police were called to the scene at 8.47am.
However, the incident was dealt with rapidly and the carriageway was clear within 15 minutes.
Pc Stuart Warne said enquiries would be conducted into what caused the Maniscopic forklift to come off the low-loader, being transported by E. Carnaby and son, of south Killingholme. Work to improve the A160 which will lead to the removal of the roundabout, is due to start in April.